challengeS

The mRNA Revolution Faces a Critical Manufacturing Bottleneck

While over hundreds of companies race to develop life-changing mRNA therapeutics, three fundamental flaws in traditional manufacturing limit their potential:
01
Quality Loss

Batch reactions compromise mRNA integrity and generate contaminants, reducing therapeutic efficacy

02
Cost & Time Barriers

Current manufacturing requires extensive purification that increases costs and extends timelines

03
Scaling Challenges

Traditional manufacturing methods require extensive re-engineering to meet demand

INTRODUCING

Waterfall Scientific's

Fluidics Platform

SolutionS

Our patented DuoTether™ technology redefines mRNA manufacturing with:

01 Continuous Flow Synthesis

Our approach anchors both the DNA template and enzyme to a solid surface, creating a continuous stream of high-quality mRNA that prevents impurity formation at the source.

02 Cleaner, More Potent mRNA

By stopping unwanted byproducts during synthesis, we deliver higher-purity mRNA that translates to stronger performance in downstream applications.

03 Reduces Costs & Time

Eliminating impurities up front cuts heavy purification steps, streamlines the entire manufacturing process, and shortens timelines.

04 Enabling Seamless Scaling

Our uniform production process works consistently from discovery to GMP/commercial manufacturing, removing the need for costly, time-consuming redesign.

01 Continuous Flow Synthesis

Our approach anchors both the DNA template and enzyme to a solid surface, creating a continuous stream of high-quality mRNA that prevents impurity formation at the source.

02 Cleaner, More Potent mRNA

By stopping unwanted byproducts during synthesis, we deliver higher-purity mRNA that translates to stronger performance in downstream applications.

03 Reduces Costs & Time

Eliminating impurities up front cuts heavy purification steps, streamlines the entire manufacturing process, and shortens timelines.

04 Enabling Seamless Scaling

Our uniform production process works consistently from discovery to GMP/commercial manufacturing, removing the need for costly, time-consuming redesign.

leadership

Meet our Team

NEWS

Waterfall Accepted to The Engine's Fall 2025 Cohort

First launched in 2020, Blueprint by The Engine™ is designed to help teams explore the translational potential for their breakthrough research and innovations. Waterfall is thrilled and honored to be accepted to the program.